With hundreds, if not thousands, of various realities in Doctor Strange in the Multiverse of Madness, it seems only natural that each of them is given a name or something to identify where one version or individual comes from. Finally, the film establishes Earth 616 as canon, the correct designation for the present reality in which the heroes find themselves.
Warning! Spoilers alert! If you haven’t watched it yet or don’t like spoilers, please don’t read!
So firstly, Strange was amazed to see Christine Palmer in another reality as a scientist who excels in learning more about the parallel worlds around the multiverse when Doctor Strange and America Chavez were taken into the Illuminati terminal after Baron Mordo lured them in by peaking their drink with a sedative.

Then Doctor Strange was astonished when Christine said that the reality they are now in is Earth 838, and Palmer explains that Strange is from Earth 616, making it canon in the MCU and the first time the universe the heroes are in has been named.

In the comics, the main timeline is also Earth 616, but there are other universes and realities where all sorts of things happen, such as the one where Wanda obliterates all of the mutants with just three words, or the ones depicted in What If…? where Ultron wins, Captain Carter becomes a super soldier, Thor is an only child, and so on.
All of these realities have a name, which follows the standard nomenclature of “Planet #,” which specifies the location and universe in which they exist. Given that the film deals with the multiverse on a grander scale, it is only natural that the many worlds be given names, as it would be confusing if they were not.
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Doctor Strange in the Multiverse of Madness is currently premiering in the cinemas.